In past work, the researchers had found that a cocktail of nine molecules could convert glial cells into new neurons. Although it was promising, the treatment was too complicated to be very practical. So the team set out to trim the number of molecules down to a more manageable amount. In the new work, they got it down to just four. In their tests on human neurons grown in culture in the lab, the researchers found that the converted neurons functioned as normal neurons would in the brain, forming networks and communicating effectively with each other.
They survived for over seven months. To see if the process could be simplified even further, the researchers also tried using just three molecules, and it also worked, albeit with a percent drop in the conversion rate. Using just one molecule, however, wasn't enough to convert cells.
According to the researchers, the beauty of this work is that the molecules could potentially be packaged into a pill. Of course, it's still very early days and there's plenty of work to do to make the treatment practical and safe, but the possibility of popping a pill to repair brain damage from Alzheimer's or strokes is an enticing future.
The research was published in the journal Stem Cell Reports. Source: Pennsylvania State University.
LOG IN. Menu HOME.
Half-mouth toothbrush cleans your teeth in 20 seconds. Architects design quirky cat shelters for non-profit. Around The Home.
Read Time:. Freda Miller and her team at the Hospital for Sick Children and the University of Toronto has determined how brain stem cells and the environment they live within collaborate to build brain circuits during development, discoveries that have led to a better understanding of neurodevelopmental disorders in children. Goldberg said. Search for topics, articles, videos, research, etc Next Steps for Development: Ultimately, if we can show that the biomaterials can improve the brain repair and movement control provided by the iPSC-derived dopamine neurons, then future clinical trials of these cells should move towards including biomaterials in the transplantation approach as this could lead to a dramatic improvement in the outcome for patients. Miller is using approaches that range from stem cell biology to transcriptomics and proteomics that identify the proteins and RNA molecules that enable stem cells to build the brain and computational modeling, with the idea that understanding brain development and repair requires an interdisciplinary and highly collaborative approach. Resolution of swelling is an important factor for the individual's function to improve.
Lenovo Smart Clock review: The perfect bedside assistant. Aluminum net-zero trailer offers luxury living off-grid.
Computer models suggest ancient Venus may have been habitable. Major molten salt nuclear fuel test completed. Research by Dr.
Freda Miller and her team at the Hospital for Sick Children and the University of Toronto has determined how brain stem cells and the environment they live within collaborate to build brain circuits during development, discoveries that have led to a better understanding of neurodevelopmental disorders in children. The Miller lab and her basic research collaborators work closely with their clinical colleagues to harness this information and develop new approaches for treating brain injury.
These results were presented at the Canadian Neuroscience Meeting, in Vancouver, May 15th, During development, the mammalian brain starts life as nothing more than a collection of stem cells that then must generate the neurons and glial cells that form the complex network of connections required for proper brain functioning and cognition. Thus far, there are many unanswered questions to whether cells from novel sources can become functional, subtype-specific and if they can restore functional deficits that relate to clinical aspects of a specific brain disease.
For many of these brain diseases, there are currently no effective treatments. Therefore the field of regeneration is at the forefront of brain research and will continue to expand and explore future possibilities for the quest for brain repair. In light of this endeavor, we bring together new evidence and compile recent efforts to regenerate the nervous system in order to electrically, structurally, and functionally repair the brain.
This Research Topic collection expects to host reviews, original research as well as hypotheses articles to showcase the recent advances and new avenues towards nervous system regeneration. Keywords : Stem cells, iPSC, reprogramming, neurodegenerative disorders, restoration. Important Note : All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements.
Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.